Manipulating the destiny of wild populations using CRISPR
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
The challenges in developing efficient and robust synthetic homing endonuclease gene drives
SAN Verkuijl, JXD Ang, L Alphey… - … in Bioengineering and …, 2022 - frontiersin.org
Making discrete and precise genetic changes to wild populations has been proposed as a
means of addressing some of the world's most pressing ecological and public health …
means of addressing some of the world's most pressing ecological and public health …
Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails
Population-scale genome modification can alter the composition or fate of wild populations.
Synthetic gene drives provide one set of tools, but their use is complicated by scientific …
Synthetic gene drives provide one set of tools, but their use is complicated by scientific …
[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …
spread throughout a population. They could potentially be used to modify or suppress pest …
Experimental demonstration of tethered gene drive systems for confined population modification or suppression
Background Homing gene drives hold great promise for the genetic control of natural
populations. However, current homing systems are capable of spreading uncontrollably …
populations. However, current homing systems are capable of spreading uncontrollably …
Modelling homing suppression gene drive in haplodiploid organisms
Y Liu, J Champer - Proceedings of the Royal Society B, 2022 - royalsocietypublishing.org
Gene drives have shown great promise for suppression of pest populations. These
engineered alleles can function by a variety of mechanisms, but the most common is the …
engineered alleles can function by a variety of mechanisms, but the most common is the …
Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives
Gene drive is a genetic engineering technology that can enable super-mendelian
inheritance of specific alleles, allowing them to spread through a population. New gene …
inheritance of specific alleles, allowing them to spread through a population. New gene …
The suppressive potential of a gene drive in populations of invasive social wasps is currently limited
Social insects are very successful invasive species, and the continued increase of global
trade and transportation has exacerbated this problem. The yellow-legged hornet, Vespa …
trade and transportation has exacerbated this problem. The yellow-legged hornet, Vespa …
Performance characteristics allow for confinement of a CRISPR toxin-antidote gene drive designed for population suppression
S Zhang, J Champer - BioRxiv, 2022 - biorxiv.org
Gene drives alleles that can bias their own inheritance are a promising way to engineer
populations for control of disease vectors, invasive species, and agricultural pests. Recent …
populations for control of disease vectors, invasive species, and agricultural pests. Recent …