Monoclonal antibodies targeting programmed cell death 1/programmed cell death ligand 1
(PD-1/PD-L1) immune checkpoints have improved the treatments of cancers. However, not …

The marine environment is a rich source of biologically active molecules for the treatment of
human diseases, especially cancer. The adaptation to unique environmental conditions led …

Nanomedicine greatly improves the efficiency in the delivery of antitumor drugs into the
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …

Cells tune adherens junction dynamics to regulate epithelial integrity in diverse (patho)
physiological processes, including cancer metastasis. We hypothesized that the spatially …

Highlights•Chemotherapy-induced neutropenia can lead to poor clinical outcomes.•CIN can
lead to infections, hospitalizations, mortality, and lower chemotherapy dose intensity.•G-CSF …

Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …

This review extensively reports data from the literature concerning the complex relationships
between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton …

Since the discovery by Madaule and Axel in 1985 of the first Ras homologue (Rho) protein
in Aplysia and its human orthologue RhoB, membership in the Rho GTPase family has …

Importance Prevention of chemotherapy-induced neutropenia (CIN) and its clinical
consequences is an unmet need for which plinabulin, a selective immunomodulating …

Simple Summary Microtubule-targeting agents are a class of chemotherapeutics used to
treat triple-negative breast cancer (TNBC). These include drugs such as eribulin that …