The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …

Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and
secondary causes and shared pathways of disease progression, correlating with substantial …

Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …

Decades of progress in developmental cardiology has advanced our understanding of the
early aspects of heart development, including cardiomyocyte (CM) differentiation. However …

Cardiogenesis is a tightly regulated dynamic process through a continuum of differentiation
and proliferation events. Key factors and pathways governing this process remain …

Mapping the chromatin occupancy of transcription factors (TFs) is a key step in deciphering
developmental transcriptional programs. Here we use biotinylated knockin alleles of seven …

Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical
cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes …

Congenital heart defects can be caused by mutations in genes that guide cardiac lineage
formation. Here, we show deletion of NKX2-5, a critical component of the cardiac gene …

Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are
genetically complex and poorly understood. Here, a multidisciplinary platform was …

Organoids, or miniaturized organs formed in vitro, hold potential to revolutionize how
researchers approach and answer fundamental biological and pathological questions. In the …