RecQ helicases and PARP1 team up in maintaining genome integrity
S Veith, A Mangerich - Ageing research reviews, 2015 - Elsevier
Genome instability represents a primary hallmark of aging and cancer. RecQL helicases (ie,
RECQL1, WRN, BLM, RECQL4, RECQL5) as well as poly (ADP-ribose) polymerases …
RECQL1, WRN, BLM, RECQL4, RECQL5) as well as poly (ADP-ribose) polymerases …
The association of low-penetrance variants in DNA repair genes with colorectal cancer: a systematic review and meta-analysis
N Aggarwal, ND Donald, S Malik… - Clinical and …, 2017 - journals.lww.com
OBJECTIVES: Approximately 35% of colorectal cancer (CRC) risk is attributable to heritable
factors known hereditary syndromes, accounting for 6%. The remainder may be due to lower …
factors known hereditary syndromes, accounting for 6%. The remainder may be due to lower …
[HTML][HTML] Base excision repair gene polymorphisms and wilms tumor susceptibility
Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions
caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and …
caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and …
Analyzing structure–function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells
L Rank, S Veith, EC Gwosch, J Demgenski… - Nucleic acids …, 2016 - academic.oup.com
Genotoxic stress activates PARP1, resulting in the post-translational modification of proteins
with poly (ADP-ribose)(PAR). We genetically deleted PARP1 in one of the most widely used …
with poly (ADP-ribose)(PAR). We genetically deleted PARP1 in one of the most widely used …
Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study
Y Deng, L Zhou, N Li, M Wang, L Yao… - Molecular …, 2019 - Wiley Online Library
Long noncoding RNA (lncRNA) polymorphisms are reportedly in connection with tumor
susceptibility and prognosis. Glioma is one of the most aggressive and common cancers of …
susceptibility and prognosis. Glioma is one of the most aggressive and common cancers of …
[HTML][HTML] Association of XPC Gene Polymorphisms with Colorectal Cancer Risk in a Southern Chinese Population: A Case-Control Study and Meta-Analysis
Xeroderma pigmentosum group C (XPC) is a key component of the nucleotide excision
repair (NER) pathway. Dysfunctional XPC protein may impair NER-mediated DNA repair …
repair (NER) pathway. Dysfunctional XPC protein may impair NER-mediated DNA repair …
[HTML][HTML] Fas expression is downregulated in gastric cancer
X Wang, Z Fu, Y Chen, L Liu - Molecular medicine …, 2017 - spandidos-publications.com
The aim of the present study was to investigate Fas expression in tumor samples from
patients with gastric cancer, in order to determine the involvement of the Fas signaling …
patients with gastric cancer, in order to determine the involvement of the Fas signaling …
[HTML][HTML] MDM4 rs4245739 A> C polymorphism correlates with reduced overall cancer risk in a meta-analysis of 69477 subjects
C Xu, J Zhu, W Fu, Z Liang, S Song, Y Zhao, L Lyu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Mouse double minute 4 (MDM4) is a p53-interacting oncoprotein that plays an
important role in the p53 tumor suppressor pathway. The common rs4245739 A> C …
important role in the p53 tumor suppressor pathway. The common rs4245739 A> C …
[HTML][HTML] DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: The role of …
The role of base excision repair (BER) genes in Philadelphia-negative (PN)-
myeloproliferative neoplasms (MPNs) susceptibility was evaluated by genotyping eight …
myeloproliferative neoplasms (MPNs) susceptibility was evaluated by genotyping eight …
[HTML][HTML] Association between Catechol-O-methyltransferase rs4680 (G> A) polymorphism and lung cancer risk
X Tan, M Chen - Diagnostic pathology, 2014 - Springer
Background The association between the Val158Met polymorphism in the catechol-O-
methyltransferase (COMT) gene and lung cancer risk remains controversial and …
methyltransferase (COMT) gene and lung cancer risk remains controversial and …