The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Genomics has provided a lever to pry open lymphoid cells and examine their regulatory
biology. The large body of available gene expression data has also allowed us to define the …

Using a mouse model recapitulating the main features of human chronic myelogenous
leukemia (CML), we uncover the hierarchy of leukemic stem and progenitor cells …

The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …

In the macrophage, toll-like receptors (TLRs) are key sensors that trigger signaling cascades
to activate inflammatory programs via the NF-κB gene network. However, the genomic …

Diffuse large B-cell lymphoma (DLBCL) consists of at least 2 phenotypic subtypes; that is,
the germinal center B-cell–like (GCB-DLBCL) and the activated B-cell–like (ABC-DLBCL) …

HOTAIRM1 is a long intergenic non-coding RNA encoded in the human HOXA gene cluster,
with gene expression highly specific for maturing myeloid cells. Knockdown of HOTAIRM1 in …

An early analysis of circulating monocytes may be critical for predicting COVID-19 course
and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival …

Objective Proinflammatory molecules promote osteoclast‐mediated bone erosion by up‐
regulating local RANKL production. However, recent evidence suggests that combinations …

Multiple studies have established that microRNAs (miRNAs) are involved in the initiation
and progression of cancer. Notably, miR-155 is one of the most overexpressed miRNAs in …