Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
RJ Rowland, R Heath, D Maskell, RF Thompson… - Scientific reports, 2023 - nature.com
Abstract p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP
family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs. p27 …
family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs. p27 …
Disorder in the human Skp1 structure is the key to its adaptability to bind many different proteins in the SCF complex assembly
Abstract Skp1 (S-phase kinase-associated protein 1-Homo sapiens) is an adapter protein of
the SCF (Skp1-Cullin1-Fbox) complex, which links the constant components (Cul1-RBX) …
the SCF (Skp1-Cullin1-Fbox) complex, which links the constant components (Cul1-RBX) …
O2 sensing–associated glycosylation exposes the F-box–combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases
Skp1 is a conserved protein linking cullin-1 to F-box proteins in SCF (Skp1/Cullin-1/F-box
protein) E3 ubiquitin ligases, which modify protein substrates with polyubiquitin chains that …
protein) E3 ubiquitin ligases, which modify protein substrates with polyubiquitin chains that …
Glycosylation promotes the random coil to helix transition in a region of a protist Skp1 associated with F-box binding
X Xu, A Eletsky, MO Sheikh, JH Prestegard… - Biochemistry, 2018 - ACS Publications
Cullin-ring-ligases mediate protein polyubiquitination, a signal for degradation in the 26S
proteasome. The CRL1 class consists of Skp1/cullin-1/F-box protein/Rbx1 (SCF) complexes …
proteasome. The CRL1 class consists of Skp1/cullin-1/F-box protein/Rbx1 (SCF) complexes …
Skp1 dimerization conceals its F-box protein binding site
HW Kim, A Eletsky, KJ Gonzalez, H Van Der Wel… - Biochemistry, 2020 - ACS Publications
Skp1 is an adapter that links F-box proteins to cullin-1 in the Skp1/cullin-1/F-box (SCF)
protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and …
protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and …
Structural Insights into How Glycosylation Controls Skp1 in Protists
HW Kim - 2022 - search.proquest.com
Skp1 is a homodimeric protein that recruits substrate receptor F-box proteins (FBP) to Cullin-
1 as part of the Skp1/Cullin-1/FBP (SCF) complex. The SCF is a class of E3 ligases that …
1 as part of the Skp1/Cullin-1/FBP (SCF) complex. The SCF is a class of E3 ligases that …
Disorder in Human Skp1 Structure is the Key to its Adaptability to Bind Many Different Proteins in the Scf Complex Assembly
A Kumar, A Bhattacharya, V Shukla - Available at SSRN 4058896 - papers.ssrn.com
Abstract Skp1 (S-phase kinase-associated protein 1-Homo sapiens) is an adapter protein of
the SCF complex, which links the constant components (Cul-1-RBX) and the variable …
the SCF complex, which links the constant components (Cul-1-RBX) and the variable …