Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
The neuroscience of placebo effects: connecting context, learning and health
Placebo effects are beneficial effects that are attributable to the brain–mind responses to the
context in which a treatment is delivered rather than to the specific actions of the drug. They …
context in which a treatment is delivered rather than to the specific actions of the drug. They …
[HTML][HTML] Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data
The brain systems underlying placebo analgesia are insufficiently understood. Here we
performed a systematic, participant-level meta-analysis of experimental functional …
performed a systematic, participant-level meta-analysis of experimental functional …
Mindfulness meditation-based pain relief employs different neural mechanisms than placebo and sham mindfulness meditation-induced analgesia
Mindfulness meditation reduces pain in experimental and clinical settings. However, it
remains unknown whether mindfulness meditation engages pain-relieving mechanisms …
remains unknown whether mindfulness meditation engages pain-relieving mechanisms …
[HTML][HTML] Placebo analgesia: a predictive coding perspective
This Perspective reviews recent findings in placebo hypoalgesia and provides a conceptual
account of how expectations and experience can lead to placebo hypoalgesia. In particular …
account of how expectations and experience can lead to placebo hypoalgesia. In particular …
Neuro-bio-behavioral mechanisms of placebo and nocebo responses: implications for clinical trials and clinical practice
The placebo effect has often been considered a nuisance in basic and particularly clinical
research. This view has gradually changed in recent years due to deeper insight into the …
research. This view has gradually changed in recent years due to deeper insight into the …
Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia
Value information about a drug, such as the price tag, can strongly affect its therapeutic
effect. We discovered that value information influences adverse treatment outcomes in …
effect. We discovered that value information influences adverse treatment outcomes in …
Placebo analgesia and its opioidergic regulation suggest that empathy for pain is grounded in self pain
Empathy for pain activates brain areas partially overlapping with those underpinning the first-
hand experience of pain. It remains unclear, however, whether such shared activations …
hand experience of pain. It remains unclear, however, whether such shared activations …
[HTML][HTML] The neurobiology shaping affective touch: expectation, motivation, and meaning in the multisensory context
Inter-individual touch can be a desirable reward that can both relieve negative affect and
evoke strong feelings of pleasure. However, if other sensory cues indicate it is undesirable …
evoke strong feelings of pleasure. However, if other sensory cues indicate it is undesirable …
Placebo effects on the neurologic pain signature: a meta-analysis of individual participant functional magnetic resonance imaging data
Importance Placebo effects reduce pain and contribute to clinical analgesia, but after
decades of research, it remains unclear whether placebo treatments mainly affect …
decades of research, it remains unclear whether placebo treatments mainly affect …