The brain constantly adapts to changes in the environment, a capability that underlies
memory and behavior. Long-term adaptations require the remodeling of neural circuits that …

The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …

Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns
during embryonic and postnatal mouse development. The loss of all miRNAs through the …

Early detection and intervention in schizophrenia requires mechanism-based biomarkers
that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of …

MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …

Schizophrenia is a chronic, heterogeneous neurodevelopmental disorder that has complex
symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics …

Long-lasting changes of brain function in response to experience rely on diverse forms of
activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long …

Genetic analyses have linked microRNA-137 (MIR137) to neuropsychiatric disorders,
including schizophrenia and autism spectrum disorder. miR-137 plays important roles in …

Epidemiological studies revealed that environmental factors comprising prenatal infection
are strongly linked to risk for later development of neuropsychiatric disorders such as …

Altered glutamate transporter expression is a common feature of many neuropsychiatric
conditions, including schizophrenia. Excitatory amino acid transporters (EAATs) are …