Antimicrobial peptides: interaction with model and biological membranes and synergism with chemical antibiotics

A Hollmann, M Martinez, P Maturana… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown
antimicrobial activity against a wide range of bacterial species, including multiresistant …

[HTML][HTML] Zeta potential beyond materials science: Applications to bacterial systems and to the development of novel antimicrobials

APVF Maillard, JC Espeche, P Maturana… - … et Biophysica Acta (BBA …, 2021 - Elsevier
This review summarizes the theory of zeta potential (ZP) and the most relevant data about
how it has been used for studying bacteria. We have especially focused on the discovery …

Design of liposomal formulations for cell targeting

E Nogueira, AC Gomes, A Preto… - Colloids and surfaces B …, 2015 - Elsevier
Liposomes have gained extensive attention as carriers for a wide range of drugs due to
being both nontoxic and biodegradable as they are composed of substances naturally …

[HTML][HTML] Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components

F Savini, MR Loffredo, C Troiano, S Bobone… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Antimicrobial peptides (AMPs) selectively kill bacteria by disrupting their cell membranes,
and are promising compounds to fight drug-resistant microbes. Biophysical studies on …

Liposomes as biomembrane models: Biophysical techniques for drug-membrane interaction studies

S Andrade, MJ Ramalho, JA Loureiro… - Journal of molecular …, 2021 - Elsevier
The interaction of drugs with biological membranes is a critical factor affecting their
pharmacokinetics and pharmacodynamics, so understanding how drugs interact with …

On the coupling between mechanical properties and electrostatics in biological membranes

VV Galassi, N Wilke - Membranes, 2021 - mdpi.com
Cell membrane structure is proposed as a lipid matrix with embedded proteins, and thus,
their emerging mechanical and electrostatic properties are commanded by lipid behavior …

[HTML][HTML] Peptide: lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional …

MC Manzini, KR Perez, KA Riske, JC Bozelli Jr… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The cecropin-melittin hybrid antimicrobial peptide BP100 (H-KKLFKKILKYL-NH2) is
selective for Gram-negative bacteria, negatively charged membranes, and weakly hemolytic …

Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives

ER Cross, SM Coulter, S Pentlavalli, G Laverty - Soft Matter, 2021 - pubs.rsc.org
The use of hydrogels has garnered significant interest as biomaterial and drug delivery
platforms for anti-infective applications. For decades antimicrobial peptides have been …

De novo design of a pH-triggered self-assembled β-hairpin nanopeptide with the dual biological functions for antibacterial and entrapment

Q Li, J Li, W Yu, Z Wang, J Li, X Feng, J Wang… - Journal of …, 2021 - Springer
Background Acid-tolerant enteric pathogens can evade small intestinal acid barriers,
colonize and infect the intestinal tract. However, broad-spectrum antibiotics are not the best …

Sensing cholesterol-induced rigidity in model membranes with time-resolved fluorescence spectroscopy and microscopy

B Biswas, D Shah, SJ Cox-Vázquez… - Journal of Materials …, 2024 - pubs.rsc.org
Here, we report the characterization of cholesterol levels on membrane fluidity with a twisted
intramolecular charge transfer (TICT) membrane dye, namely DI-8-ANEPPS, using …