Chromatin plasticity: a versatile landscape that underlies cell fate and identity
T Yadav, JP Quivy, G Almouzni - Science, 2018 - science.org
During development and throughout life, a variety of specialized cells must be generated to
ensure the proper function of each tissue and organ. Chromatin plays a key role in …
ensure the proper function of each tissue and organ. Chromatin plays a key role in …
The molecular and cellular features of 2-cell-like cells: a reference guide
M Genet, ME Torres-Padilla - Development, 2020 - journals.biologists.com
Currently, two main cell culture models predominate pluripotent stem cell research:
embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Thanks to their …
embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Thanks to their …
[HTML][HTML] Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
M Yang, H Yu, X Yu, S Liang, Y Hu, Y Luo, Z Izsvák… - Cell Stem Cell, 2022 - cell.com
Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …
[HTML][HTML] 8C-like cells capture the human zygotic genome activation program in vitro
J Taubenschmid-Stowers, M Rostovskaya, F Santos… - Cell stem cell, 2022 - cell.com
The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …
Mouse totipotent stem cells captured and maintained through spliceosomal repression
Since establishment of the first embryonic stem cells (ESCs), in vitro culture of totipotent cells
functionally and molecularly comparable with in vivo blastomeres with embryonic and …
functionally and molecularly comparable with in vivo blastomeres with embryonic and …
Evaluating totipotency using criteria of increasing stringency
E Posfai, JP Schell, A Janiszewski, I Rovic… - Nature cell …, 2021 - nature.com
Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely …
build the conceptus, yet how to capture this property in vitro remains incompletely …
Derivation of totipotent-like stem cells with blastocyst-like structure forming potential
Y Xu, J Zhao, Y Ren, X Wang, Y Lyu, B Xie, Y Sun… - Cell Research, 2022 - nature.com
It is challenging to derive totipotent stem cells in vitro that functionally and molecularly
resemble cells from totipotent embryos. Here, we report that a chemical cocktail enables the …
resemble cells from totipotent embryos. Here, we report that a chemical cocktail enables the …
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
Abstract N6-methyladenosine (m6A) on chromosome-associated regulatory RNAs
(carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and …
(carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and …
p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models
In mammalian embryos, proper zygotic genome activation (ZGA) underlies totipotent
development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is …
development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is …
DNA replication fork speed underlies cell fate changes and promotes reprogramming
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …
characterized. In the present study, we employed DNA fiber analysis to investigate how …