MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate
gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the …

Cancer is one of the leading cause of death in the world with the prevalence of> 10 million
mortalities annually. Current cancer treatments include surgical intervention, radiation, and …

The small regulatory RNA microRNA-21 (miR-21) plays a crucial role in a plethora of
biological functions and diseases including development, cancer, cardiovascular diseases …

Background MicroRNAs (miRNAs) have been implicated in cancer initiation and
progression via their ability to affect expression of genes and proteins that regulate cell …

The role of the extracellular non-coding RNAs, particularly microRNAs present in tumor-
derived extravesicles, has been intensively exploited in human cancer as a promising tool …

MicroRNAs (miRNAs) are small, single-stranded, endogenous non-coding RNAs that
repress the expression of target genes via post-transcriptional mechanisms. Due to their …

The human genome encodes at least 14 DNA-dependent DNA polymerases—a surprisingly
large number. These include the more abundant, high-fidelity enzymes that replicate the …

The transcription factor ZEB1 is normally not expressed in epithelial cells. When
inappropriately expressed in carcinomas, ZEB1 initiates epithelial to mesenchymal transition …

We identified a key oncogenic pathway underlying neuroblastoma progression: specifically,
MYCN, expressed at elevated level, transactivates the miRNA 17-5p-92 cluster, which …

MicroRNAs are a highly conserved group of small, non-coding RNA molecules, which are
19-25 nucleotides in size. Previously thought to be evolutionary debris with no evident …