Dynamics and specificities of T cells in cancer immunotherapy
G Oliveira, CJ Wu - Nature Reviews Cancer, 2023 - nature.com
Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …
Can we predict T cell specificity with digital biology and machine learning?
Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …
solutions to problems such as protein structure prediction that were long thought to be …
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting
M Charabati, MA Wheeler, HL Weiner, FJ Quintana - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
CA Klebanoff, SS Chandran, BM Baker… - Nature Reviews Drug …, 2023 - nature.com
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
Neoantigens: promising targets for cancer therapy
Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
Foxp3-expressing CD4+ CD25+ regulatory T cells (Tregs) constitutively and highly express
the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) …
the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) …
Cell type-specific delivery by modular envelope design
The delivery of genetic cargo remains one of the largest obstacles to the successful
translation of experimental therapies, in large part due to the absence of targetable delivery …
translation of experimental therapies, in large part due to the absence of targetable delivery …
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence
Y Xu, GH Su, D Ma, Y Xiao, ZM Shao… - Signal Transduction and …, 2021 - nature.com
Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …
Alternative mRNA splicing in cancer immunotherapy
L Frankiw, D Baltimore, G Li - Nature Reviews Immunology, 2019 - nature.com
Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages
Tissue macrophages (Mϕ) are essential effector cells in rheumatoid arthritis (RA),
contributing to autoimmune tissue inflammation through diverse effector functions. Their …
contributing to autoimmune tissue inflammation through diverse effector functions. Their …