Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

Foxp3-expressing CD4+ CD25+ regulatory T cells (Tregs) constitutively and highly express
the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) …

The delivery of genetic cargo remains one of the largest obstacles to the successful
translation of experimental therapies, in large part due to the absence of targetable delivery …

Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …

Tissue macrophages (Mϕ) are essential effector cells in rheumatoid arthritis (RA),
contributing to autoimmune tissue inflammation through diverse effector functions. Their …