Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Renal fibrosis is the usual outcome of an excessive accumulation of extracellular matrix
(ECM) that frequently occurs in membranous and diabetic nephropathy. The result of renal …

Albuminuria associated with sclerosis of the glomerulus leads to a progressive decline in
renal function affecting millions of people. Here we report that activation of the Notch …

T-cell acute lymphoblastic leukaemia (T-ALL) is induced by the transformation of T-cell
progenitors and mainly occurs in children and adolescents. Although treatment outcome in …

Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. It is also the
third most common cancer diagnosis among men, and the second most common cancer …

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles
during vascular development and physiology in vertebrates. These roles include regulation …

Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays
myriad roles during vascular development and physiology in vertebrates. These roles …

Vascular morphogenesis encompasses a temporally regulated set of morphological
changes that endothelial cells undergo to generate a network of interconnected tubules …

The Notch pathway plays an important role in regulating epidermal differentiation. Notch
ligands, receptors and effectors are expressed in a complex and dynamic pattern in …