CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …

Acetylation, a key component in post-translational modification regulated by HATs and
HDACs, is relevant to many crucial cellular contexts in organisms. Based on crucial …

Acetylation of histone and non-histone protein lysine residues has been widely described as
a critical modulator of several cell functions in humans. Lysine acetyltransferases (KATs) …

Histone‐modifying enzymes are the key regulators involved in the post‐translational
modification of histone and non‐histone. These enzymes are responsible for the epigenetic …

KAT8 is a lysine acetyltransferase primarily catalyzing the acetylation of Lys16 of histone H4
(H4K16). KAT8 dysregulation is linked to the development and metastatization of many …

Literature evidence that natural products are potential bioactive components for lead
compounds in drug discovery. These molecules have distinctive chemical structures that …

This review aims to provide a comprehensive report on the quinoline ring with respect to its
synthesis, reactivity, and therapeutic values. The reactivity of quinoline for the metal …

A [4+ 2] annulation involving cascade Knoevenagel, aza-Wittig and dehydrofluorination
reactions is developed for the synthesis of substituted quinolin-4-ols including analogs …

Recently we described some (thiazol-2-yl) hydrazones as antiprotozoal, antifungal and anti-
MAO agents as well as Gcn5 HAT inhibitors. Among these last compounds, CPTH2 and …

Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic
failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3 …