Detection of amyloid beta peptides in body fluids for the diagnosis of alzheimer's disease: Where do we stand?

B Veerabhadrappa, C Delaby, C Hirtz… - Critical reviews in …, 2020 - Taylor & Francis
Alzheimer's disease (AD) is an incurable neurodegenerative disease characterized by
progressive decline of cognitive abilities. Amyloid beta peptides (Aβ), Tau proteins and the …

Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015)

V Kašička - Electrophoresis, 2016 - Wiley Online Library
The review brings a comprehensive survey of recent developments and applications of high
performance capillary and microchip electroseparation methods (zone electrophoresis …

Single-step immunoassays and microfluidic droplet operation: Towards a versatile approach for detection of amyloid-β peptide-based biomarkers of Alzheimer's …

TD Mai, D Ferraro, N Aboud, R Renault, M Serra… - Sensors and Actuators B …, 2018 - Elsevier
In this study, single-step magnetic-beads based immunoassays was developed and for the
first time adapted to microfluidic droplet operation for sequential determination of well …

[HTML][HTML] Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer's disease than AβX–42/X–40?

HW Klafki, B Morgado, O Wirths, O Jahn… - Fluids and Barriers of …, 2022 - Springer
Background A reduced amyloid-β (Aβ) 42/40 peptide ratio in blood plasma represents a
peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer's disease …

[HTML][HTML] A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising …

H Shahpasand-Kroner, HW Klafki, C Bauer… - Alzheimer's Research & …, 2018 - Springer
Background The quantification of amyloid-beta (Aβ) peptides in blood plasma as potential
biomarkers of Alzheimer's disease (AD) is hampered by very low Aβ concentrations and the …

[HTML][HTML] Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

TJ Oberstein, P Spitzer, HW Klafki, P Linning… - Neurobiology of …, 2015 - Elsevier
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic
plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ …

Capillary electrophoresis–based immunoassay and aptamer assay: A review

H Nevídalová, L Michalcová, Z Glatz - Electrophoresis, 2020 - Wiley Online Library
Over the last two decades, the group of techniques called affinity probe CE has been widely
used for the detection and the determination of several types of biomolecules with high …

A novel sandwich-type photoelectrochemical immunosensor based on Ru (bpy) 32+ and Ce-CdS co-sensitized hierarchical ZnO matrix and dual-inhibited polystyrene …

D Fan, X Liu, C Bao, J Feng, H Wang, H Ma… - Biosensors and …, 2019 - Elsevier
A novel and sensitive sandwich-type photoelectrochemical (PEC) immunosensor was
developed for the quantitative detection of β-amyloid protein (Aβ). A ITO electrode was …

[HTML][HTML] N-truncated Aβ4–x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models

O Wirths, S Walter, I Kraus, HW Klafki, M Stazi… - Alzheimer's research & …, 2017 - Springer
Background The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain
parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer's …

N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer's disease

S Zampar, HW Klafki, K Sritharen… - Neuropathology and …, 2020 - Wiley Online Library
Aims The deposition of amyloid‐β (Aβ) peptides in the form of extracellular plaques in the
brain represents one of the classical hallmarks of Alzheimer's disease (AD). In addition to …