The role of bile acids in carcinogenesis

T Režen, D Rozman, T Kovács, P Kovács… - Cellular and molecular …, 2022 - Springer
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer

H Zeng, S Umar, B Rust, D Lazarova… - International journal of …, 2019 - mdpi.com
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …

Fiber, fat, and colorectal cancer: new insight into modifiable dietary risk factors

S Ocvirk, AS Wilson, CN Appolonia, TK Thomas… - Current …, 2019 - Springer
Abstract Purpose of Review To review recent data on the role and interactions of fiber and
fat as dietary risk factors associated with colorectal cancer (CRC) risk in humans. Recent …

Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium

RO Corrêa, PR Castro, JL Fachi, VD Nirello… - Microbiome, 2023 - Springer
Background The continuous proliferation of intestinal stem cells followed by their tightly
regulated differentiation to epithelial cells is essential for the maintenance of the gut …

[HTML][HTML] Bile acids and cancer: direct and environmental-dependent effects

A Di Ciaula, DQH Wang, E Molina-Molina… - Annals of hepatology, 2017 - Elsevier
Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but
have also a key role as signaling molecules and in the modulation of epithelial cell …

Interplay between dysbiosis of gut microbiome, lipid metabolism, and tumorigenesis: can gut dysbiosis stand as a prognostic marker in cancer?

I Chattopadhyay, R Gundamaraju, NK Jha… - Disease …, 2022 - Wiley Online Library
The gut bacterial community is involved in the metabolism of bile acids and short‐chain fatty
acids (SCFAs). Bile acids are involved in the absorption of fat and the regulation of lipid …

Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis: Linking dietary …

H Zeng, SK Hamlin, BD Safratowich, WH Cheng… - Nutrition Research, 2020 - Elsevier
Intake of dietary fiber may protect against colon cancer. The anticancer property is
associated with an increased production of short chain fatty acids (SCFAs), including …

Microbial metabolites and intestinal stem cells tune intestinal homeostasis

PY Xing, S Pettersson, P Kundu - Proteomics, 2020 - Wiley Online Library
Microorganisms that colonize the gastrointestinal tract, collectively known as the gut
microbiota, are known to produce small molecules and metabolites that significantly …

The bile acids, deoxycholic acid and ursodeoxycholic acid, regulate colonic epithelial wound healing

MS Mroz, NK Lajczak, BJ Goggins… - American Journal of …, 2018 - journals.physiology.org
The intestinal epithelium constitutes an innate barrier which, upon injury, undergoes self-
repair processes known as restitution. Although bile acids are known as important regulators …

Hyodeoxycholic acid (HDCA) suppresses intestinal epithelial cell proliferation through FXR‐PI3K/AKT pathway, accompanied by alteration of bile acids metabolism …

M Song, Q Yang, F Zhang, L Chen, H Su… - The FASEB …, 2020 - Wiley Online Library
Bile acids (BAs) have been implicated in regulation of intestinal epithelial signaling and
function. This study aimed to investigate the effects of hyodeoxycholic acid (HDCA) on …