Optimization of metabolomic data processing using NOREVA

J Fu, Y Zhang, Y Wang, H Zhang, J Liu, J Tang… - Nature protocols, 2022 - nature.com
A typical output of a metabolomic experiment is a peak table corresponding to the intensity
of measured signals. Peak table processing, an essential procedure in metabolomics, is …

Statistical analysis in metabolic phenotyping

BJ Blaise, GDS Correia, GA Haggart, I Surowiec… - Nature …, 2021 - nature.com
Metabolic phenotyping is an important tool in translational biomedical research. The
advanced analytical technologies commonly used for phenotyping, including mass …

NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data

Q Yang, Y Wang, Y Zhang, F Li, W Xia… - Nucleic acids …, 2020 - academic.oup.com
Biological processes (like microbial growth & physiological response) are usually dynamic
and require the monitoring of metabolic variation at different time-points. Moreover, there is …

Data normalization strategies in metabolomics: Current challenges, approaches, and tools

BB Misra - European Journal of Mass Spectrometry, 2020 - journals.sagepub.com
Data normalization is a big challenge in quantitative metabolomics approaches, whether
targeted or untargeted. Without proper normalization, the mass-spectrometry and …

Pharmacometabonomics: data processing and statistical analysis

J Fu, Y Zhang, J Liu, X Lian, J Tang… - Briefings in …, 2021 - academic.oup.com
Individual variations in drug efficacy, side effects and adverse drug reactions are still
challenging that cannot be ignored in drug research and development. The aim of …

Metabolomics meets systems immunology

J Fu, F Zhu, CJ Xu, Y Li - EMBO reports, 2023 - embopress.org
Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …

Investigating the effect of Ti3C2 (MXene) nanosheet on human umbilical vein endothelial cells via a combined untargeted and targeted metabolomics approach

D Zhang, W Zheng, X Li, A Li, N Ye, L Zhang, Y Liu… - Carbon, 2021 - Elsevier
Ti 3 C 2 is the first member of two-dimensional (2D) transition metal carbide or carbonitride
(MXene) with excellent photothermal effect in disease treatment on an animal model, which …

Integrated metabolomics revealed the fibromyalgia-alleviation effect of Mo2C nanozyme through regulated homeostasis of oxidative stress and energy metabolism

D Zhang, L Jiang, L Li, X Li, W Zheng, L Gui, Y Yang… - Biomaterials, 2022 - Elsevier
Fibromyalgia (FM), the most common cause of chronic musculoskeletal pain in the general
public, lacks advanced therapeutic methodology and detailed bioinformation. However …

Contribution of upregulated aminoacyl‐tRNA biosynthesis to metabolic dysregulation in gastric cancer

X Gao, R Guo, Y Li, G Kang, Y Wu… - Journal of …, 2021 - Wiley Online Library
Abstract Background and Aim Metabolic reprogramming is characterized by dysregulated
levels of metabolites and metabolic enzymes. Integrated metabolomic and transcriptomic …

Tools and resources for metabolomics research community: A 2017–2018 update

BB Misra, S Mohapatra - Electrophoresis, 2019 - Wiley Online Library
The scale at which MS‐and NMR‐based platforms generate metabolomics datasets for both
research, core, and clinical facilities to address challenges in the various sciences—ranging …