The extracellular compartments of most biological tissues are significantly less well
protected against oxidative damage than intracellular sites and there is considerable …

Chronic obstructive pulmonary disease, characterised by a slowly progressive, irreversible
airways limitation, is a major worldwide cause of chronic morbidity and mortality. The …

Objective—The involvement of transition metals in atherosclerosis is controversial. Some
epidemiological studies have reported a relationship between iron (Fe) and cardiovascular …

There is accumulating evidence that damage to extracellular materials and particularly the
extracellular matrix, can play a major role in multiple human pathologies. In contrast to cells …

We studied potential indicators of severe acute pancreatitis by measuring the blood
concentrations of various cytokines, polymorphonuclear leucocyte elastase (PMN‐E), acute …

Voluminous literature exists on the mechanisms by which cells and tissues are destroyed in
infectious and inflammatory sites. Microbial toxins,'their enzymes ''and cell-wall …

The degradation of the heparan sulfate proteoglycans of subendothelial matrix by neutrophil
elastase and the myeloperoxidase-H2O2-chloride system added separately, sequentially, or …

Background. Elastase activity in cancer cells has been reported to promote their metastasis.
Hence, we analyzed the influence of elastase activity of cancer cells on their responsive …

Many viruses cause encephalitis, but understanding the mechanisms by which viral infection
leads to encephalopathy or dementia remain elusive. In many cases, inflammation …

The mechanisms of cellular damage caused by infectious and inflammatory processes are
complex and are still not fully understood. There is, however, a consensus that reactive …