Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin
family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates …

Genome replication and assembly of viruses often takes place in specific intracellular
compartments where viral components concentrate, thereby increasing the efficiency of the …

Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific …

There is an urgent need for antivirals to treat the newly emerged severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a …

Virions are thought to contain all the essential proteins that govern virus egress from the host
cell and initiation of replication in the target cell. It has been known for some time that …

Poxviruses comprise a large family of viruses characterized by a large, linear dsDNA
genome, a cytoplasmic site of replication and a complex virion morphology. The most …

To identify the function of HAb18G/CD147 in invasion of host cells by severe acute
respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction …

Coronaviruses infect a variety of mammalian and avian species and cause serious diseases
in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS) …

Vaccinia virus is a large enveloped poxvirus with more than 200 genes in its genome.
Although many poxvirus genomes have been sequenced, knowledge of the host and viral …

The antiretroviral restriction factor TRIM5 has recently emerged as an important mediator of
innate immunity and species-specific inhibition of retroviral replication in mammals …