[HTML][HTML] Acetaminophen hepatotoxicity
A Ramachandran, H Jaeschke - Seminars in liver disease, 2019 - thieme-connect.com
Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …
However, due to its wide availability, it is frequently implicated in intentional or unintentional …
[HTML][HTML] Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential
Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …
However, its source, pathophysiological role and possible therapeutic potential if targeted …
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose
Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …
Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure
Liver injury and acute liver failure caused by acetaminophen (APAP, N-acetyl-p-
aminophenol, paracetamol) overdose is a significant clinical problem in most western …
aminophenol, paracetamol) overdose is a significant clinical problem in most western …
[HTML][HTML] Acetaminophen toxicity: novel insights into mechanisms and future perspectives
A Ramachandran, H Jaeschke - Gene expression, 2018 - ncbi.nlm.nih.gov
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …
and decades of intense study of its pathogenesis resulted in the development of the antidote …
[HTML][HTML] Animal models of drug-induced liver injury
MR McGill, H Jaeschke - Biochimica et Biophysica Acta (BBA)-Molecular …, 2019 - Elsevier
Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and
regulators. It is the most common cause of acute liver failure in the US. It is also one of the …
regulators. It is the most common cause of acute liver failure in the US. It is also one of the …
[HTML][HTML] Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives
A Ramachandran, RGJ Visschers, L Duan… - Journal of clinical and …, 2018 - ncbi.nlm.nih.gov
Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …
recognized as playing important roles in cellular signaling. Their central role in energy …
[HTML][HTML] Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …
Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice
Background & Aims Acetaminophen (APAP)-induced liver injury is the most frequent cause
of acute liver failure in the US and many other countries. Metabolism of APAP results in …
of acute liver failure in the US and many other countries. Metabolism of APAP results in …
[HTML][HTML] Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
A Ramachandran, H Jaeschke - Journal of clinical and translational …, 2017 - ncbi.nlm.nih.gov
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
United States and mechanisms of liver injury induced by APAP overdose have been the …
United States and mechanisms of liver injury induced by APAP overdose have been the …