Multi-omics approaches to define calcific aortic valve disease pathogenesis
Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
Biology and biomechanics of the heart valve extracellular matrix
KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
In situ remodeling overrules bioinspired scaffold architecture of supramolecular elastomeric tissue-engineered heart valves
M Uiterwijk, AIPM Smits, D van Geemen… - Basic to Translational …, 2020 - jacc.org
In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an
affordable and practical approach for heart valve replacement; therefore, it is attractive for …
affordable and practical approach for heart valve replacement; therefore, it is attractive for …
Fabrication and characterization of a 3D scaffold based on elastomeric poly-glycerol Sebacate polymer for heart valve applications
M Atari, S Labbaf, SH Javanmard - Journal of Manufacturing Processes, 2023 - Elsevier
Heart valve disease is one of the major reasons for cardiovascular complications and
mortalities worldwide. Despite significant breakthroughs in multiple valve designs with …
mortalities worldwide. Despite significant breakthroughs in multiple valve designs with …
An ultrasound-exclusive non-invasive computational diagnostic framework for personalized cardiology of aortic valve stenosis
Aortic stenosis (AS) is an acute and chronic cardiovascular disease and If left untreated,
50% of these patients will die within two years of developing symptoms. AS is characterized …
50% of these patients will die within two years of developing symptoms. AS is characterized …
Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays
In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis-
and calcification-induced tissue stiffening, further driving pathophysiology. No …
and calcification-induced tissue stiffening, further driving pathophysiology. No …
The cellular mechanobiology of aging: from biology to mechanics
Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …
changes in living organisms. Aging is associated with permanent, gradual physiological …
Long-term stability and biocompatibility of pericardial bioprosthetic heart valves
DF Williams, D Bezuidenhout, J De Villiers… - Frontiers in …, 2021 - frontiersin.org
The use of bioprostheses for heart valve therapy has gradually evolved over several
decades and both surgical and transcatheter devices are now highly successful. The rapid …
decades and both surgical and transcatheter devices are now highly successful. The rapid …
Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms
MA Oyama, C Elliott, KA Loughran, AP Kossar… - Cardiovascular …, 2020 - Elsevier
Myxomatous mitral valve degeneration (MMVD) is a leading cause of valve repair or
replacement secondary to the production of mitral regurgitation, cardiac enlargement …
replacement secondary to the production of mitral regurgitation, cardiac enlargement …
A detailed mechanical and microstructural analysis of ovine tricuspid valve leaflets
The tricuspid valve ensures unidirectional blood flow from the right atrium to the right
ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear …
ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear …