Multi-omics approaches to define calcific aortic valve disease pathogenesis

MC Blaser, S Kraler, TF Lüscher, E Aikawa - Circulation research, 2021 - Am Heart Assoc
Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …

Biology and biomechanics of the heart valve extracellular matrix

KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

In situ remodeling overrules bioinspired scaffold architecture of supramolecular elastomeric tissue-engineered heart valves

M Uiterwijk, AIPM Smits, D van Geemen… - Basic to Translational …, 2020 - jacc.org
In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an
affordable and practical approach for heart valve replacement; therefore, it is attractive for …

Fabrication and characterization of a 3D scaffold based on elastomeric poly-glycerol Sebacate polymer for heart valve applications

M Atari, S Labbaf, SH Javanmard - Journal of Manufacturing Processes, 2023 - Elsevier
Heart valve disease is one of the major reasons for cardiovascular complications and
mortalities worldwide. Despite significant breakthroughs in multiple valve designs with …

An ultrasound-exclusive non-invasive computational diagnostic framework for personalized cardiology of aortic valve stenosis

N Bahadormanesh, B Tomka, M Kadem… - Medical Image …, 2023 - Elsevier
Aortic stenosis (AS) is an acute and chronic cardiovascular disease and If left untreated,
50% of these patients will die within two years of developing symptoms. AS is characterized …

Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays

CL Clift, MC Blaser, W Gerrits, ME Turner… - Science …, 2024 - science.org
In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis-
and calcification-induced tissue stiffening, further driving pathophysiology. No …

The cellular mechanobiology of aging: from biology to mechanics

A Bajpai, R Li, W Chen - Annals of the New York Academy of …, 2021 - Wiley Online Library
Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …

Long-term stability and biocompatibility of pericardial bioprosthetic heart valves

DF Williams, D Bezuidenhout, J De Villiers… - Frontiers in …, 2021 - frontiersin.org
The use of bioprostheses for heart valve therapy has gradually evolved over several
decades and both surgical and transcatheter devices are now highly successful. The rapid …

Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms

MA Oyama, C Elliott, KA Loughran, AP Kossar… - Cardiovascular …, 2020 - Elsevier
Myxomatous mitral valve degeneration (MMVD) is a leading cause of valve repair or
replacement secondary to the production of mitral regurgitation, cardiac enlargement …

A detailed mechanical and microstructural analysis of ovine tricuspid valve leaflets

WD Meador, M Mathur, GP Sugerman, T Jazwiec… - Acta biomaterialia, 2020 - Elsevier
The tricuspid valve ensures unidirectional blood flow from the right atrium to the right
ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear …