Human memory T cells: generation, compartmentalization and homeostasis
Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …
majority of a person's lifetime; however, our understanding of memory T cell generation …
Mucosal resident memory CD4 T cells in protection and immunopathology
Tissue-resident memory T cells (TRM) comprise a newly defined subset, which comprises a
major component of lymphocyte populations in diverse peripheral tissue sites, including …
major component of lymphocyte populations in diverse peripheral tissue sites, including …
Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection
We identify in this article a new class of lung tissue-resident memory CD4 T cells that exhibit
tissue tropism and retention independent of Ag or inflammation. Tissue-resident memory …
tissue tropism and retention independent of Ag or inflammation. Tissue-resident memory …
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
The threat of avian influenza A (H5N1) infection in humans remains a global health concern.
Current influenza vaccines stimulate antibody responses against the surface glycoproteins …
Current influenza vaccines stimulate antibody responses against the surface glycoproteins …
Harnessing the power of T cells: the promising hope for a universal influenza vaccine
EB Clemens, C Van de Sandt, SS Wong, LM Wakim… - Vaccines, 2018 - mdpi.com
Next-generation vaccines that utilize T cells could potentially overcome the limitations of
current influenza vaccines that rely on antibodies to provide narrow subtype-specific …
current influenza vaccines that rely on antibodies to provide narrow subtype-specific …
Local heroes or villains: tissue-resident memory T cells in human health and disease
Tissue-resident memory T (TRM) cells are increasingly associated with the outcomes of
health and disease. TRM cells can mediate local immune protection against infections and …
health and disease. TRM cells can mediate local immune protection against infections and …
H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses
P Moris, R van der Most, I Leroux-Roels… - Journal of clinical …, 2011 - Springer
Objective Adjuvantation of an H5N1 split-virion influenza vaccine with AS03 A substantially
reduces the antigen dose required to produce a putatively protective humoral response and …
reduces the antigen dose required to produce a putatively protective humoral response and …
Heterosubtypic T-cell immunity to influenza in humans: challenges for universal T-cell influenza vaccines
S Sridhar - Frontiers in immunology, 2016 - frontiersin.org
Influenza A virus (IAV) remains a significant global health issue causing annual epidemics,
pandemics, and sporadic human infections with highly pathogenic avian or swine influenza …
pandemics, and sporadic human infections with highly pathogenic avian or swine influenza …
CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection
JE Kohlmeier, T Cookenham, SC Miller… - The Journal of …, 2009 - journals.aai.org
Effector T cells are a crucial component of the adaptive immune response to respiratory virus
infections. Although it was previously reported that the chemokine receptors CCR5 and …
infections. Although it was previously reported that the chemokine receptors CCR5 and …
Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells
Respiratory syncytial virus (RSV) infection is one of the leading causes of infant
hospitalization and a major health and economic burden worldwide. Infection with this virus …
hospitalization and a major health and economic burden worldwide. Infection with this virus …