The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …
development and tissue regeneration. However, aberrant reactivation of EMT is associated …
Dynamic EMT: a multi‐tool for tumor progression
S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds
HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
JM Banales, JJG Marin, A Lamarca… - Nature reviews …, 2020 - nature.com
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …
Guidelines and definitions for research on epithelial–mesenchymal transition
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
[HTML][HTML] RHOJ controls EMT-associated resistance to chemotherapy
M Debaugnies, S Rodríguez-Acebes, J Blondeau… - Nature, 2023 - nature.com
The resistance of cancer cells to therapy is responsible for the death of most patients with
cancer. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to …
cancer. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to …
Mechanisms of cancer metastasis
M Castaneda, P den Hollander, NA Kuburich… - Seminars in cancer …, 2022 - Elsevier
Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …
Bone metastasis: mechanisms, therapies, and biomarkers
Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …
EMT transition states during tumor progression and metastasis
I Pastushenko, C Blanpain - Trends in cell biology, 2019 - cell.com
Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …
Pharmacological targeting of netrin-1 inhibits EMT in cancer
Epithelial-to-mesenchymal transition (EMT) regulates tumour initiation, progression,
metastasis and resistance to anti-cancer therapy,,,,,–. Although great progress has been …
metastasis and resistance to anti-cancer therapy,,,,,–. Although great progress has been …