Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

Parkinson disease

W Poewe, K Seppi, CM Tanner, GM Halliday… - Nature reviews Disease …, 2017 - nature.com
Parkinson disease is the second-most common neurodegenerative disorder that affects 2–
3% of the population≥ 65 years of age. Neuronal loss in the substantia nigra, which causes …

[HTML][HTML] Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease

D Sulzer, C Cassidy, G Horga, UJ Kang, S Fahn… - NPJ Parkinson's …, 2018 - nature.com
The diagnosis of Parkinson's disease (PD) occurs after pathogenesis is advanced and many
substantia nigra (SN) dopamine neurons have already died. Now that therapies to block this …

Imaging the substantia nigra in Parkinson disease and other Parkinsonian syndromes

YJ Bae, JM Kim, CH Sohn, JH Choi, BS Choi, YS Song… - Radiology, 2021 - pubs.rsna.org
Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the
midbrain. There are various imaging markers for Parkinson disease. Recent advances in …

[HTML][HTML] Magnetic resonance imaging for the diagnosis of Parkinson's disease

B Heim, F Krismer, R De Marzi, K Seppi - Journal of neural transmission, 2017 - Springer
The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

[HTML][HTML] The concept of prodromal Parkinson's disease

P Mahlknecht, K Seppi… - Journal of Parkinson's …, 2015 - content.iospress.com
Parkinson's disease (PD) is currently clinically defined by a set of cardinal motor features
centred on the presence of bradykinesia and at least one additional motor symptom out of …

[HTML][HTML] Neuromelanin imaging and dopaminergic loss in Parkinson's disease

IU Isaias, P Trujillo, P Summers, G Marotta… - Frontiers in aging …, 2016 - frontiersin.org
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major
pathologic substrate is a loss of dopaminergic neurons from the substantia nigra. Our main …

Meta‐analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease

P Mahlknecht, F Krismer, W Poewe… - Movement …, 2017 - Wiley Online Library
Background Dorsolateral nigral hyperintensity on iron‐sensitive magnetic resonance
imaging (MRI) sequences seems to be a typical finding in Parkinson's disease (PD), but …

[HTML][HTML] Imaging the Nigrosome 1 in the substantia nigra using susceptibility weighted imaging and quantitative susceptibility mapping: An application to Parkinson's …

Z Cheng, N He, P Huang, Y Li, R Tang, SK Sethi… - NeuroImage: Clinical, 2020 - Elsevier
Parkinson's disease (PD) is a clinically heterogeneous chronic progressive neuro-
degenerative disease with loss of dopaminergic neurons in the nigrosome 1 (N1) territory of …

[HTML][HTML] Neuroimaging at 7 Tesla: a pictorial narrative review

T Okada, K Fujimoto, Y Fushimi, T Akasaka… - … imaging in medicine …, 2022 - ncbi.nlm.nih.gov
Abstract Neuroimaging using the 7-Tesla (7T) human magnetic resonance (MR) system is
rapidly gaining popularity after being approved for clinical use in the European Union and …