Relationship between p53 status and the bioeffect of ionizing radiation
X Kong, D Yu, Z Wang, S Li - Oncology letters, 2021 - spandidos-publications.com
Radiotherapy is widely used in the clinical treatment of cancer patients and it may be used
alone or in combination with surgery or chemotherapy to inhibit tumor development …
alone or in combination with surgery or chemotherapy to inhibit tumor development …
Extracellular Matrix Proteins Confer Cell Adhesion-Mediated Drug Resistance Through Integrin αv in Glioblastoma Cells
Chemotherapy resistance to glioblastoma (GBM) remains an obstacle that is difficult to
overcome, leading to poor prognosis of GBM patients. Many previous studies have focused …
overcome, leading to poor prognosis of GBM patients. Many previous studies have focused …
[HTML][HTML] Butein inhibits cancer cell growth by rescuing the wild-type thermal stability of mutant p53
B Song, J Wang, Y Ren, Y Su, X Geng, F Yang… - Biomedicine & …, 2023 - Elsevier
Abstract p53 is a transcription factor that activates the expression of various genes involved
in the maintenance of genomic stability, and more than 50% of cancers harbor inactivating …
in the maintenance of genomic stability, and more than 50% of cancers harbor inactivating …
CF3‐pyridinyl substitution on antimalarial therapeutics: probing differential ligand binding and dynamical inhibitory effects of a novel triazolopyrimidine‐based inhibitor …
The quest for reliable dihydroorotate dehydrogenase (DHODH) inhibitors has engendered
the discovery of potential therapeutic compounds at different stages of clinical trials …
the discovery of potential therapeutic compounds at different stages of clinical trials …
[HTML][HTML] Does size really matter? Probing the efficacy of structural reduction in the optimization of bioderived compounds–A computational “proof-of-concept”
Over the years, numerous synthetic approaches have been utilized in drug design to
improve the pharmacological properties of naturally derived compounds and most …
improve the pharmacological properties of naturally derived compounds and most …
DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice
The tumor suppressor p53 is the most common mutated gene in cancer, with the R175H as
the most frequent p53 missense mutant. However, there are currently no approved targeted …
the most frequent p53 missense mutant. However, there are currently no approved targeted …
Triple Mycobacterial ATP-synthase mutations impedes Bedaquiline binding: Atomistic and structural perspectives
Bedaquiline (BDQ) has demonstrated formidable bactericidal activity towards
Mycobacterium tuberculosis (Mtb) in the treatment of multi-drug resistant (MDR) and …
Mycobacterium tuberculosis (Mtb) in the treatment of multi-drug resistant (MDR) and …
Exploration of alternate therapeutic remedies in Ebola virus disease: the case of reported antiviral phytochemical derived from the leaves Spondias Mombin Linn
A Boadu, R Karpoormath, M Nlooto - Advances in Traditional Medicine, 2023 - Springer
The most common and lethal of the six strains of Ebola viruses (EBOV) causing the
Ebolavirus disease is the Zaire EBOV and has an approximately 90% mortality rate of …
Ebolavirus disease is the Zaire EBOV and has an approximately 90% mortality rate of …
Deciphering the 'Elixir of Life': Dynamic perspectives into the allosteric modulation of mitochondrial ATP synthase by J147, a novel drug in the treatment of Alzheimer's …
The discovery of J147 represented a significant milestone in the treatment of age‐related
disorders, which was further augmented by the recent identification of mitochondrial ATP …
disorders, which was further augmented by the recent identification of mitochondrial ATP …
Halting ionic shuttle to disrupt the synthetic machinery—Structural and molecular insights into the inhibitory roles of Bedaquiline towards Mycobacterium tuberculosis …
Therapeutic targeting of the adenosine triphosphate (ATP) machinery of Mycobacterium
tuberculosis (Mtb) has recently presented a potent and alternative measure to halt the …
tuberculosis (Mtb) has recently presented a potent and alternative measure to halt the …