Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …

Recently, the long non-coding RNA (lncRNA) NEAT1 has been identified as an oncogenic
gene in multiple cancer types and elevated expression of NEAT1 was tightly linked to …

Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …

Abstract Hsa-miRNA-326 (miR-326) has recently been discovered having anticancer
efficacy in different organs. However, the role of miR-326 on non-small cell lung cancer …

SMYD3 is a member of the SMYD lysine methylase family and plays an important role in the
methylation of various histone and non-histone targets. Aberrant SMYD3 expression …

Abstract Hsa-miRNA-134 (miR-134) has recently been discovered to have anticancer
efficacy in different organs. However, the role of miR-134 on non-small cell lung cancer …

Prostate cancer is one of the most common non-cutaneous malignancies among men
worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or …

Radiotherapy (RT) is one of the mainstay treatments for prostate cancer (PCa), a highly
prevalent neoplasm among males worldwide. About 30% of newly diagnosed PCa patients …

Background Histone methylation, as an essential pattern of posttranslational modifications,
contributes to multiple cancer-related biological processes. Dysregulation of histone …