The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …

Cancer cells evade T cell-mediated killing through tumour–immune interactions whose
mechanisms are not well understood,. Dendritic cells (DCs), especially type-1 conventional …

In metazoan organisms, cell competition acts as a quality control mechanism to eliminate
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …

The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that
controls the cellular response to environmental cues by exerting its kinase activity on …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular
and organismal growth, and hyperactivation of this pathway is implicated in the …

Kidney cancer is not a single disease but represents several distinct types of cancer that
have defining histologies and genetic alterations and that follow different clinical courses …

The mTORC1 kinase is a master growth regulator that senses numerous environmental
cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino …

Kidney cancer is not a single disease but comprises a number of different types of cancer
that occur in the kidney, each caused by a different gene with a different histology and …