Interplay between mechanics and signalling in regulating cell fate
Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …
organisms, including cell fate transitions, cell migration, morphogenesis and immune …
Fluorescent probes for lipid membranes: from the cell surface to organelles
AS Klymchenko - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Biomembranes are ubiquitous lipid structures that delimit the cell surface and
organelles and operate as platforms for a multitude of biomolecular processes. The …
organelles and operate as platforms for a multitude of biomolecular processes. The …
Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
K Hiratsuka, T Miyoshi, KT Kroll, NR Gupta… - Science …, 2022 - science.org
Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …
A polarity‐sensitive ratiometric fluorescence probe for monitoring changes in lipid droplets and nucleus during ferroptosis
Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid
peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets …
peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets …
[HTML][HTML] Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis
The ongoing metabolic and microbicidal pathways that support and protect cellular life
generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells …
generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells …
Targeted solvatochromic fluorescent probes for imaging lipid order in organelles under oxidative and mechanical stress
DI Danylchuk, PH Jouard… - Journal of the American …, 2021 - ACS Publications
Biomembranes constitute a basis for all compartments of live cells, and therefore, the
monitoring of their lipid organization is essential for understanding cell status and activity …
monitoring of their lipid organization is essential for understanding cell status and activity …
[HTML][HTML] Heterochromatin-driven nuclear softening protects the genome against mechanical stress-induced damage
MM Nava, YA Miroshnikova, LC Biggs, DB Whitefield… - Cell, 2020 - cell.com
Tissue homeostasis requires maintenance of functional integrity under stress. A central
source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how …
source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how …
Passive coupling of membrane tension and cell volume during active response of cells to osmosis
During osmotic changes of their environment, cells actively regulate their volume and
plasma membrane tension that can passively change through osmosis. How tension and …
plasma membrane tension that can passively change through osmosis. How tension and …
Design and application of fluorescent probes to detect cellular physical microenvironments
The microenvironment is indispensable for functionality of various biomacromolecules,
subcellular compartments, living cells, and organisms. In particular, physical properties …
subcellular compartments, living cells, and organisms. In particular, physical properties …
[HTML][HTML] Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …
neural activity in deep brain regions with high spatial precision and without chemical or …