Cancer, more than any other human disease, now has a surfeit of potential molecular targets
poised for therapeutic exploitation. Currently, a number of attractive and validated cancer …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

In this paper, we developed a rhodium-catalyzed annulation of vinylene carbonate with
amidines, leading to 4-methylquinazolines with moderate to excellent yields. This procedure …

The signal transducer and activator of transcription 3 (STAT3) protein is a master regulator of
most key hallmarks and enablers of cancer, including cell proliferation and the response to …

High-risk neuroblastoma (NB) accounts for 15% of all pediatric cancer deaths. Refractory
disease for high-risk NB patients is attributed to chemotherapy resistance and …

Small molecules are used in the G‐quadruplex (G4) research field in vivo and in vitro, and
there are increasing demands for ligands that selectively stabilize different G4 structures …

We report herein a high-temperature and high-pressure continuous-flow protocol to carry out
nucleophilic aromatic substitution (SN Ar) of heterocycles with nitrogen nucleophiles …

Abstract Structure–activity relationship studies of a 1, 2, 4-triazolo-[3, 4-b] thiadiazine
scaffold, identified in an HTS campaign for selective STAT3 pathway inhibitors, determined …

Signal transducer and activator of transcription factor 3 (STAT3) is hyperactivated in head
and neck squamous cell carcinomas (HNSCC). Cumulative evidence indicates that IL-6 …

An easy and efficient approach to the synthesis of N, 4-disubstituted quinazoline-2-amine
and oxides is described. This transformation proceeds smoothly in the presence of …