Background It has become increasingly common to consider BRCA mutation status when
determining optimal cancer risk management and treatment options in order to improve …

Objective Cancer genetic counseling increasingly involves discussing uncertain test results,
for example because multiple genes are sequenced simultaneously. This review was …

Background Sequence-based BRCA testing can identify variants of unknown significance
(VUS). Relatively little is known about how well a test outcome of VUS is understood by …

Studies suggest that patients carrying a BRCA variant of uncertain significance (VUS) may
have lingering confusion concerning results interpretation. Counseling for uninformative …

Background: It has been hypothesized that the Outcomes of DNA testing (O) are better
predicted and/or mediated by the counselees' Perception P) than by the actually …

The value of genomic risk assessment depends upon patients making appropriate
behavioral changes in response to increased risk leading to disease prevention and early …

Purpose Clinical genome sequencing produces uncertain diagnostic results, raising
concerns about how to communicate the method's inherent complexities in ways that reduce …

Background: Advances in next-generation sequencing (NGS) technologies are driving a
shift from single-gene to multigene panel testing for clinical genetic cancer risk assessment …

Background Several studies have shown that counselees do not experience
psychopathological levels of distress after DNA test result disclosure. However, it has not …

OBJECTIVE: Previous studies suggest that learning a DNA-test-result has no direct impact
on the medical-decisions and psychological well-being of counselees. Their perception …