m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

RNA m6A methylation in cancer

Z Wang, J Zhou, H Zhang, L Ge, J Li… - Molecular …, 2023 - Wiley Online Library
N 6‐methyladenosine (m6A) is one of the most abundant internal modifications in eukaryotic
messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic …

[HTML][HTML] The m6A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia

L Sang, X Wu, T Yan, D Naren, X Liu, X Zheng… - Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m 6 A) is the most abundant internal modification in
mammalian mRNA and recent studies have highlighted the importance of m 6 A levels in …

Fumonisin B1 alters global m6A RNA methylation and epigenetically regulates Keap1-Nrf2 signaling in human hepatoma (HepG2) cells

T Arumugam, T Ghazi, AA Chuturgoon - Archives of Toxicology, 2021 - Springer
FB 1 is a common contaminant of cereal grains that affects human and animal health. It has
become increasingly evident that epigenetic changes are implicated in FB 1 toxicity. N 6 …

The impact of epitranscriptomic modifications on liver disease

KA Berggren, RE Schwartz, RE Kleiner… - Trends in Endocrinology & …, 2024 - cell.com
RNA modifications have emerged as important mechanisms of gene regulation.
Developmental, metabolic, and cell cycle regulatory processes are all affected by …

Interaction between N6-methyladenosine (m6A) modification and environmental chemical-induced diseases in various organ systems

X Zhu, H Fu, J Sun, Q Xu - Chemico-Biological Interactions, 2023 - Elsevier
A wide variety of chemicals are ubiquitous in the environment and thus exposure to these
environmental chemicals poses a serious threat to public health. Particularly, environmental …

Mettl3 promotes oxLDL‐mediated inflammation through activating STAT1 signaling

Z Li, Q Xu, N Huangfu, X Chen… - Journal of clinical …, 2022 - Wiley Online Library
Background Atherosclerosis (AS) is the main cause of cerebrovascular diseases, and
macrophages act important roles during the AS pathological process through regulating …

RNA Demethylase ALKBH5 Prevents Lung Cancer Progression by Regulating EMT and Stemness via Regulating p53

X Liu, Z Wang, Q Yang, X Hu, Q Fu, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Background Although N6-methyladenosine (m6A) RNA methylation is the most abundant
reversible methylation of mRNA, which plays a critical role in regulating cancer processing …

N6-methyladenosine methylation regulator FTO promotes oxidative stress and induces cell apoptosis in ovarian cancer

J Wu, X Wang, X Li - Epigenomics, 2022 - Taylor & Francis
Aims: This study aimed to reveal the possible molecular mechanism of n6-methyladenosine
(m6A) methylation regulator FTO in the biological activities of ovarian cancer (OC) based on …

Establishing a novel colorectal cancer predictive model based on unique gut microbial single nucleotide variant markers

C Ma, K Chen, Y Wang, C Cen, Q Zhai, J Zhang - Gut Microbes, 2021 - Taylor & Francis
Current metagenomic species-based colorectal cancer (CRC) microbial biomarkers may
confuse diagnosis because the genetic content of different microbial strains, even those …