Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

Introduction A classification framework for posterior cortical atrophy (PCA) is proposed to
improve the uniformity of definition of the syndrome in a variety of research settings. Methods …

PURPOSE OF REVIEW Early-onset Alzheimer disease (AD) is defined as having an age of
onset younger than 65 years. While early-onset AD is often overshadowed by the more …

Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …

The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated
to combine both patient care and research. Together, to date, all patients forming the …

Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's
disease (AD) and by their caretakers. Working memory and long-term declarative memory …

Importance Previous postmortem studies have long demonstrated that neurofibrillary tangles
made of hyperphosphorylated tau proteins are closely associated with Alzheimer disease …

We assessed patterns of gray matter atrophy according to-age-at-onset in a large sample of
215 Alzheimer's disease (AD) patients and 129 control subjects with voxel-based …

Cognitive, behavioural, and functional assessment is crucial in longitudinal studies of
neurodegenerative dementias (NDD). Central issues, such as the definition of the study …