Abstract mRNA is packaged into ribonucleoprotein particles called mRNPs. A multitude of
RNA-binding proteins as well as a host of associated proteins participate in the fate of …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Protein–RNA interactions regulate RNA fate and function, and defects can lead to various
disorders. Such interactions have mainly been studied by nucleoside-based UV crosslinking …

Splicing of pre-mRNAs critically contributes to gene regulation and proteome expansion in
eukaryotes, but our understanding of the recognition and pairing of splice sites during …

Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins
typically attain the physiological specificity and affinity for their RNA targets by combining …

Eukaryotic cells determine the final protein output of their genetic program not only by
controlling transcription but also by regulating the localization, translation and turnover rates …

Many proteins contain more than one folded domain, and such modular multi‐domain
proteins help expand the functional repertoire of proteins. Because of their larger size and …

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …

RNA-binding proteins (RBPs) regulate RNA metabolism at multiple levels by affecting
splicing of nascent transcripts, RNA folding, base modification, transport, localization …

Many RNA-binding proteins contain multiple single-strand nucleic acid-binding domains
and assemble into large multiprotein messenger ribonucleic acid protein (mRNP) …