Although previously restricted to a limited number of medical conditions, there is a growing
appreciation that 'autoimmune'(or immune-mediated) processes are important aspects of a …

Immunoglobulin class switch recombination (CSR) plays critical roles in controlling
infections and inflammatory tissue injuries. Here, we show that AFF3, a candidate gene for …

Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor
CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers …

Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM),
continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell lineages …

Objective To explore the shared gene signatures and potential molecular mechanisms of
polyarticular juvenile idiopathic arthritis (pJIA) and autoimmune uveitis (AU). Method The …

microRNA (miRNA)–messenger RNA (mRNA or gene) interactions are pivotal in various
biological processes, including the regulation of gene expression, cellular differentiation …

Atopic dermatitis (AD) is a common chronic skin inflammation. It was to screen differentially
expressed genes (DEGs) and related biological functional pathways in atopic dermatitis …

T cells constitute an essential component of the adaptive immune response to immunogenic
antigens both endogenous and exogenous such as those from allergens or viral infections …

Macrophages elicit immune responses to pathogens through induction of inflammatory
genes. Here, we examined the role of three variants of the SWI/SNF nucleosome remodeling …