[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

MEDIATE-Molecular DockIng at homE: Turning collaborative simulations into therapeutic solutions

G Vistoli, C Manelfi, C Talarico, A Fava… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Collaborative computing has attracted great interest, enabling researchers
worldwide to come together and work seamlessly. Its relevance has never been so apparent …

DeepCoVDR: deep transfer learning with graph transformer and cross-attention for predicting COVID-19 drug response

Z Huang, P Zhang, L Deng - Bioinformatics, 2023 - academic.oup.com
Motivation The coronavirus disease 2019 (COVID-19) remains a global public health
emergency. Although people, especially those with underlying health conditions, could …

[HTML][HTML] Systematic down-selection of repurposed drug candidates for COVID-19

CA MacRaild, MUR Mohammed, Faheem… - International journal of …, 2022 - mdpi.com
SARS-CoV-2 is the cause of the COVID-19 pandemic which has claimed more than 6.5
million lives worldwide, devastating the economy and overwhelming healthcare systems …

[HTML][HTML] Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery

W Chiu, J Schepers, T Francken, L Vangeel, K Abbasi… - Antiviral research, 2023 - Elsevier
Massive efforts on both vaccine development and antiviral research were launched to
combat the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We …

[HTML][HTML] Multiplexed multicolor antiviral assay amenable for high-throughput research

LH Li, W Chiu, YA Huang, M Rasulova… - Nature …, 2024 - nature.com
To curb viral epidemics and pandemics, antiviral drugs are needed with activity against
entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay …

[HTML][HTML] Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex

M Kuzikov, J Reinshagen, K Wycisk, A Corona… - Virus Research, 2024 - Elsevier
Coronaviruses contain one of the largest genomes among the RNA viruses, coding for 14–
16 non-structural proteins (nsp) that are involved in proteolytic processing, genome …

[HTML][HTML] Target Prediction by Multiple Virtual Screenings: Analyzing the SARS-CoV-2 Phenotypic Screening by the Docking Simulations Submitted to the MEDIATE …

S Gervasoni, C Manelfi, S Adobati, C Talarico… - International Journal of …, 2023 - mdpi.com
Phenotypic screenings are usually combined with deconvolution techniques to characterize
the mechanism of action for the retrieved hits. These studies can be supported by various …

Alliance of heart and endoderm: multilineage organoids to model co-development

WH Ng, B Varghese, H Jia, X Ren - Circulation research, 2023 - Am Heart Assoc
Studies in animal models tracing organogenesis of the mesoderm-derived heart have
emphasized the importance of signals coming from adjacent endodermal tissues in …

[HTML][HTML] Effects of usnic acid to prevent infections by creating a protective barrier in an in vitro study

R Galla, S Ferrari, S Ruga, B Mantuano… - International Journal of …, 2023 - mdpi.com
Nasal sprays are medical devices useful for preventing infection and the subsequent spread
of airborne pathogens. The effectiveness of these devices depends on the activity of chosen …