Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …

Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Telomeric ends of chromosomes, which comprise noncoding repeat sequences of guanine-
rich DNA, are fundamental in protecting the cell from recombination and degradation 1 …

Type I photodynamic therapy (PDT) represents a promising treatment modality for tumors
with intrinsic hypoxia. However, type I photosensitizers (PSs), especially ones with near …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Molecular self‐assembly is central to many processes in both biology and supramolecular
chemistry. The G‐quartet, a hydrogen‐bonded macrocycle formed by cation‐templated …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

We report here the results of a systematic search for the existence and prevalence of
potential intramolecular G-quadruplex forming sequences in the human genome. We have …

Efficient nuclear DNA damage and release is highly recommended to improve the
photodynamic immunotherapy by eliciting innate immune response yet remains challenging …