Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Photodynamic therapy (PDT) has been extensively investigated for decades for tumor
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound
energy (photoacoustic imaging, PAI) has been intensively investigated for the treatment and …
energy (photoacoustic imaging, PAI) has been intensively investigated for the treatment and …
Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …
Near‐infrared‐light‐activatable nanomaterial‐mediated phototheranostic nanomedicines: an emerging paradigm for cancer treatment
R Vankayala, KC Hwang - Advanced Materials, 2018 - Wiley Online Library
Cancer is one of the most deadly diseases threatening the lives of humans. Although many
treatment methods have been developed to tackle cancer, each modality of cancer treatment …
treatment methods have been developed to tackle cancer, each modality of cancer treatment …
Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer?
Nanotechnology offers several attractive design features that have prompted its exploration
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
H Maeda, H Nakamura, J Fang - Advanced drug delivery reviews, 2013 - Elsevier
The EPR effect results from the extravasation of macromolecules or nanoparticles through
tumor blood vessels. We here provide a historical review of the EPR effect, including its …
tumor blood vessels. We here provide a historical review of the EPR effect, including its …
[HTML][HTML] Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?
H Kobayashi, R Watanabe, PL Choyke - Theranostics, 2014 - ncbi.nlm.nih.gov
Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …
such as a larger loading capacity, the ability to protect the payload until delivery, more …
A retrospective 30 years after discovery of the enhanced permeability and retention effect of solid tumors: next‐generation chemotherapeutics and photodynamic …
H Maeda, K Tsukigawa, J Fang - Microcirculation, 2016 - Wiley Online Library
Solid tumor has unique vascular architecture, excessive production of vascular mediators,
and extravasation of macromolecules from blood vessels into the tumor tissue interstitium …
and extravasation of macromolecules from blood vessels into the tumor tissue interstitium …
Au Nanorod Design as Light-Absorber in the First and Second Biological Near-Infrared Windows for in Vivo Photothermal Therapy
Photothermal cancer therapy using near-infrared (NIR) laser radiation is an emerging
treatment. In the NIR region, two biological transparency windows are located in 650–950 …
treatment. In the NIR region, two biological transparency windows are located in 650–950 …
Polysaccharide-based nanocarriers for efficient transvascular drug delivery
M Zhang, H Ma, X Wang, B Yu, H Cong… - Journal of Controlled …, 2023 - Elsevier
Polysaccharide-based nanocarriers (PBNs) are the focus of extensive investigation because
of their biocompatibility, low cost, wide availability, and chemical versatility, which allow a …
of their biocompatibility, low cost, wide availability, and chemical versatility, which allow a …