Intercellular communication among cancer cells and their microenvironment is crucial to
disease progression. The mechanisms by which communication occurs between distant …

Highlights•New drugs are required to treat glioblastoma and limit resistance.•Gemcitabine
displays specific advantages over temozolomide.•Gemcitabine immunomodulating capacity …

Malignant pleural mesothelioma is a particularly aggressive and locally invasive malignancy
with a poor prognosis despite advances in understanding of cancer cell biology and …

Glioblastoma multiforme (GBM) is the most aggressive astrocytoma, and therapeutic options
are generally limited to surgical resection, radiotherapy, and Temozolomide (TMZ) …

Tumor-targeted delivery of anticancer drugs using dendrimers has been recognized as a
promising strategy to increase efficiency and reduce adverse effects of chemotherapy …

Investigation of potential therapeutics for targeting breast cancer stem cells (BCSCs) is
important because these cells are regarded as culprit of breast cancer relapse …

Pancreatic cancer (PC) is one of the most deadly and quickly fatal human cancers with a 5-
year mortality rate close to 100%. Its prognosis is very poor, mainly because of its hostile …

The therapy resistance of pancreatic cancer is associated with the loss of gap junction
intercellular communication and connexin 43 expression. The broccoli isothiocyanate …

Nanotechnology has been successfully used for the fabrication of targeted anti-cancer drug
carriers. This study aimed to obtain Fe3O4 nanoparticles functionalized with Gemcitabine to …

Locally initiated RNA interference (RNAi) has the potential for spatial propagation, inducing
posttranscriptional gene silencing in distant cells. In Caenorhabditis elegans, systemic RNAi …