Microneedle arrays for drug delivery and diagnostics: toward an optimized design, reliable insertion, and penetration

V Ebrahiminejad, PD Prewett… - Advanced Materials …, 2022 - Wiley Online Library
In the past two decades, microneedles have been extensively studied for transdermal
delivery of drug or vaccines and for bio‐fluid extraction. Microneedle‐based devices consist …

[HTML][HTML] Insights into the mechanics of solid conical microneedle array insertion into skin using the finite element method

W Shu, H Heimark, N Bertollo, DJ Tobin… - Acta Biomaterialia, 2021 - Elsevier
In order to develop optimum microneedle designs, researchers must first develop robust,
repeatable and adaptable test methods which are representative of in vivo conditions …

Forensic veterinary pathology: sharp injuries in animals

A De Siqueira, SEC Cuevas, FA Salvagni… - Veterinary …, 2016 - journals.sagepub.com
Sharp-force injuries are injuries caused by a mechanical force using sharp objects against
the skin. Sharp-force injuries are mainly classified as stab, incised, chop, and therapeutic …

[图书][B] Simpson's forensic medicine

J Payne-James, RM Jones - 2019 - taylorfrancis.com
Prestigious and authoritative, this fully updated fourteenth edition of Simpson's Forensic
Medicine remains a classic; one of the world's leading introductory texts in the field of …

The biomechanics of autoinjector-skin interactions during dynamic needle insertion

VD Sree, A Ardekani, P Vlachos, AB Tepole - Journal of Biomechanics, 2022 - Elsevier
Autoinjector devices are rapidly becoming the preferred method of drug delivery for a wide
array of pharmaceuticals such as monoclonal antibodies. Yet, our understanding of injection …

Honeybee stinger-based biopsy needle and influence of the barbs on needle forces during insertion/extraction into the iliac crest: a multilayer finite element approach

R Nadda, R Repaka, AK Sahani - Computers in Biology and Medicine, 2023 - Elsevier
Bone marrow biopsy (BMB) needles are frequently used in medical procedures, including
extracting biological tissue to identify specific lesions or abnormalities discovered during a …

Piercing the surface: a mechanical analysis of stabbing with household tools

V Heckmann, V Engum, G Simon… - Journal of forensic …, 2023 - Wiley Online Library
Estimating the applied power during a stabbing incident, or estimating the minimal force
necessary to penetrate the body with a certain weapon is a challenging task in forensic …

Assessment of bacterial nanocellulose loaded with acetylsalicylic acid or povidone-iodine as bioactive dressings for skin and soft tissue infections

S Argel, M Castaño, DE Jimenez, S Rodríguez… - Pharmaceutics, 2022 - mdpi.com
Bacterial nanocellulose (BNC) is a novel nanomaterial known for its large surface area,
biocompatibility, and non-toxicity. BNC contributes to regenerative processes in the skin but …

The hyperelastic and failure behaviors of skin in relation to the dynamic application of microscopic penetrators in a murine model

SC Meliga, JW Coffey, ML Crichton, C Flaim, M Veidt… - Acta biomaterialia, 2017 - Elsevier
In-depth understanding of skin elastic and rupture behavior is fundamental to enable next-
generation biomedical devices to directly access areas rich in cells and biomolecules …

Mechanical damage in porcine dermis: Micro-mechanical model and experimental characterization

JT Tubon, VD Sree, J Payne, L Solorio… - Journal of the Mechanical …, 2023 - Elsevier
Skin is subjected to extreme mechanical loading during needle insertion and drug delivery
to the subcutaneous space. There is a rich literature on the characterization of porcine skin …