The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

Epidemiological studies have established that many tumours occur in association with
persistent inflammation. One clear example of inflammation-related cancer is hepatocellular …

Epidermal growth factor receptor (EGFR)-mediated signaling is required for optimal
intestinal wound healing. Since n-3 polyunsaturated fatty acids (PUFA), specifically …

The rhomboid family are evolutionary conserved intramembrane proteases. Their inactive
members, iRhom in Drosophila melanogaster and iRhom1 and iRhom2 in mammals, lack …

Cyclooxygenase‐2 (COX‐2) plays an important role in tumorigenesis through prostaglandin
E2 (PGE2) biosynthesis. It has been shown by in vitro studies that PGE2 signaling …

Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA.
Colorectal cancer progression and metastasis depends on the orchestration of the aberrant …

A disintegrin and metalloproteinase (ADAM) family members are known to process the
target membrane-bound molecules through the quick induction of their protease activities …

Accumulating evidence indicates that inflammation plays a critical role in cancer
development. Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme for prostanoid …

Background We have previously found that TLR4-deficient (TLR4-/-) mice demonstrate
decreased expression of mucosal PGE 2 and are protected against colitis-associated …

To identify gene expression biomarkers and pathways targeted by sulindac and erlotinib
given in a chemoprevention trial with a significant decrease in duodenal polyp burden at 6 …