The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Objective Gastric cancer is the second leading cause of cancer-related deaths and the fifth
most common malignancy worldwide. In this study, human and mouse gastric cancer …

Adenine base editing (ABE) enables enzymatic conversion from AT into GC base pairs. ABE
holds promise for clinical application, as it does not depend on the introduction of double …

In mice, intestinal tuft cells have been described as a long-lived, postmitotic cell type. Two
distinct subsets have been identified: tuft-1 and tuft-2 (ref.). By combining analysis of primary …

Prime editing is a recently reported genome editing tool using a nickase-cas9 fused to a
reverse transcriptase that directly synthesizes the desired edit at the target site. Here, we …

Optimization of CRISPR/Cas9-mediated genome engineering has resulted in base editors
that hold promise for mutation repair and disease modeling. Here, we demonstrate the …

Gastric cancer ranks as the fifth most common human malignancy and the third leading
cause of cancer related deaths. Depending on tumor stage, endoscopic or surgical resection …

METTL3 and METTL14 are two components that form the core heterodimer of the main RNA
m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 …

Background Organoids are in vitro three-dimensional structures that can be grown from
patient tissue. Head and neck cancer (HNC) is a collective term used for multiple tumor …