Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals.
The disease was initially described in the 16th century and was the first animal pathogen …

Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

Cell survival in changing environments requires appropriate regulation of gene expression,
including translational control. Multiple stress signaling pathways converge on several key …

Current understanding of the molecular basis of pathogenesis of foot-and-mouth disease
(FMD) has been achieved through over 100 years of study into the biology of the etiologic …

Initiation of translation in eukaryotic cells can occur by two distinct mechanisms, cap-
dependent scanning and internal ribosome entry. The latter mechanism requires the …

Unlike bacterial protein synthesis, eukaryotic protein synthesis has several mechanisms to
initiate translation including cap-dependent initiation, re-initiation and internal initiation …

Investigation into the pathogenesis of foot‐and‐mouth disease (FMD) has focused on the
study of the disease in cattle with less emphasis on pigs, small ruminants and …

IRES elements are highly structured RNA sequences that function to recruit ribosomes for
the initiation of translation. In contrast to the canonical cap-binding, ribosome-scanning …

Initiation of translation from most cellular mRNAs occurs via scanning; the 40 S ribosomal
subunit binds to the m 7 G-cap and then moves along the mRNA until an initiation codon is …

The nucleocapsid protein VP30 of Ebola virus (EBOV), a member of the Filovirus family, is
known to act as a transcription activator. By using a reconstituted minigenome system, the …