Genome-resolved metagenomics: a game changer for microbiome medicine

N Kim, J Ma, W Kim, J Kim, P Belenky… - Experimental & Molecular …, 2024 - nature.com
Recent substantial evidence implicating commensal bacteria in human diseases has given
rise to a new domain in biomedical research: microbiome medicine. This emerging field …

Sequencing-based analysis of microbiomes

Y Pinto, AS Bhatt - Nature Reviews Genetics, 2024 - nature.com
Microbiomes occupy a range of niches and, in addition to having diverse compositions, they
have varied functional roles that have an impact on agriculture, environmental sciences, and …

Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation

B Shi, H Li, X He - Gut Microbes, 2024 - Taylor & Francis
The gut microbiome is known as the tenth system of the human body that plays a vital role in
the intersection between health and disease. The considerable inter-individual variability in …

Precision probiotics supplement strategy in aging population based on gut microbiome composition

YF Chuang, KC Fan, YY Su, MF Wu… - Briefings in …, 2024 - academic.oup.com
With the increasing prevalence of age-related chronic diseases burdening healthcare
systems, there is a pressing need for innovative management strategies. Our study focuses …

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Z Yu, M Guo, B Yu, Y Wang, Z Yan, R Gao - Frontiers in Microbiology, 2024 - frontiersin.org
Background Anorexia nervosa (AN) and bulimia nervosa (BN) poses a significant challenge
to global public health. Despite extensive research, conclusive evidence regarding the …

Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue

C He, Y An, L Shi, Y Huang, H Zhang, W Fu… - Frontiers in …, 2024 - frontiersin.org
Metabolic syndrome (MetS) is a clinical condition associated with multiple metabolic risk
factors leading to type 2 diabetes mellitus and other metabolic diseases. Recent evidence …

[HTML][HTML] Pervasive selective sweeps across human gut microbiomes

R Wolff, NR Garud - bioRxiv, 2023 - ncbi.nlm.nih.gov
The human gut microbiome is composed of a highly diverse consortia of species which are
continually evolving within and across hosts. The ability to identify adaptations common to …

Gut microbiome co-abundance networks varies with age, sex, smoking status and body mass index

C Boetto, V Basten Romero, L Henches, A Frouin… - medRxiv, 2024 - medrxiv.org
The gut microbiome is a complex ecosystem whose members develop local interactions to
form coherent functional communities. Variability in these communities, typically investigated …

[HTML][HTML] Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice

Q Zhang, ER Hutchison, C Pan, MF Warren, MP Keller… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The molecular basis for how host genetic variation impacts gut microbial community and
bacterial metabolic niches remain largely unknown. We leveraged 90 inbred hyperlipidemic …

Microbiome-wide PheWAS links gut microbial SNVs to human health and exposures

J Fu, D Wang, S Andreu-Sánchez, H Peng… - 2024 - researchsquare.com
The importance of the gut microbiome in human health has been widely recognized, with
alterations in species abundances now reported for many different diseases. In recent years …