Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

Mitochondrial creatine kinase (MtCK), together with cytosolic creatine kinase isoenzymes
and the highly diffusible CK reaction product, phosphocreatine, provide a temporal and …

Metabolic imaging of the relative amounts of reduced NADH and FAD and the
microenvironment of these metabolic electron carriers can be used to noninvasively monitor …

Objectives: We investigated cardiac energetics in subjects with mutations in three different
familial hypertrophic cardiomyopathy (HCM) disease genes, some of whom were …

Mitochondrial dysfunction is implicated in a number of skeletal muscle pathologies, most
notably aging-induced atrophy and loss of type II myofibers. Although oxygen-derived free …

In skeletal muscle, two major types of muscle fibers exist: slow-twitch oxidative (type I) fibers
designed for low-intensity long-lasting contractions, and fast-twitch glycolytic (type II) fibers …

Beyond their fundamental role in energy metabolism, mitochondria perform a great variety of
other important cellular functions. However, the interplay among these various roles of …

A growing body of research is investigating the potential contribution of mitochondrial
function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo …

Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …

The fundamental principle of cardiac behaviour is described by the Frank‐Starling law
relating force of contraction during systole with end‐diastolic volume. While both work and …