The cornea is a complex sensory organ that must maintain its transparency for optimal
vision. Infections such as with herpes simplex virus can result in blinding …

HSV-1 infection of the cornea leads to a blinding immunoinflammatory lesion of the eye
termed stromal keratitis (SK). Recently, IL-17–producing CD4+ T cells (Th17 cells) were …

Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally
alymphatic cornea, a process that compromises the cornea's immune-privileged state and …

Ocular infection with HSV causes corneal neovascularization (CV), an essential step in the
pathogenesis of the blinding immunoinflammatory lesion stromal keratitis. The infection …

The normal cornea is transparent, which is essential for normal vision, and although the
angiogenic factor vascular endothelial growth factor A (VEGF-A) is present in the cornea, its …

Ocular herpes simplex virus infection can cause a blinding CD4+ T cell orchestrated
immuno-inflammatory lesion in the cornea called Stromal Keratitis (SK). A key to controlling …

Herpes simplex 1 infection of the eye can cause blindness with lesions in the corneal stroma
largely attributable to inflammatory events that include components of both adaptive and …

Abstract After HSV-1 infection, CD8+ T cells accumulate in the trigeminal ganglion (TG) and
participate in the maintenance of latency. However, the mechanisms underlying intermittent …

Purpose: Blinding ocular herpetic disease in humans is due to spontaneous reactivation of
herpes simplex virus type 1 (HSV-1) from latency, rather than to primary acute infection. Mice …

Ocular infection with herpes simplex virus 1 (HSV-1) results in a chronic
immunoinflamammtory reaction in the cornea, which is primarily orchestrated by CD4+ T …