IGF binding proteins in cancer: mechanistic and clinical insights
RC Baxter - Nature Reviews Cancer, 2014 - nature.com
The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …
were originally characterized as passive reservoirs of circulating IGFs, but they are now …
Saponins as modulators of nuclear receptors
T Zhang, S Zhong, T Li, J Zhang - Critical reviews in food science …, 2020 - Taylor & Francis
As plant-derived natural products, saponins have been widely applied for the dietary
modification of metabolic syndrome. However, the underlying mechanisms of their …
modification of metabolic syndrome. However, the underlying mechanisms of their …
[HTML][HTML] UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely
targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation …
targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation …
[HTML][HTML] Nuclear hormone receptor co-repressors: structure and function
PJ Watson, L Fairall, JWR Schwabe - Molecular and cellular endocrinology, 2012 - Elsevier
Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of
unliganded nuclear receptors and other transcription factors. They appear to act as …
unliganded nuclear receptors and other transcription factors. They appear to act as …
Recent development in ecdysone receptor of crustaceans: current knowledge and future applications in crustacean aquaculture
MR Abdullah‐Zawawi, N Afiqah‐Aleng… - Reviews in …, 2021 - Wiley Online Library
Ecdysone receptor (EcR) is the primary regulator of the ecdysteroid signalling pathway, a
critical pathway that directly links to moulting. In addition, EcR also regulates growth …
critical pathway that directly links to moulting. In addition, EcR also regulates growth …
[HTML][HTML] Nuclear receptors in liver fibrosis
Nuclear receptors are ligand-activated transcription factors that regulate gene expression of
a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver …
a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver …
The marionette mechanism of domain–domain communication in the antagonist, agonist, and coactivator responses of the estrogen receptor
The human estrogen receptor α (hER α) is involved in the regulation of growth,
development, and tissue homeostasis. Agonists that bind to the receptor's ligand-binding …
development, and tissue homeostasis. Agonists that bind to the receptor's ligand-binding …
FXR: structures, biology, and drug development for NASH and fibrosis diseases
S Tian, S Chen, C Pan, Y Li - Acta Pharmacologica Sinica, 2022 - nature.com
The nuclear receptor farnesoid-X-receptor (FXR) plays an essential role in bile acid,
glucose, and lipid homeostasis. In the last two decades, several diseases, such as obesity …
glucose, and lipid homeostasis. In the last two decades, several diseases, such as obesity …
[HTML][HTML] Nuclear receptors as multiple regulators of NLRP3 inflammasome function
A Alatshan, S Benkő - Frontiers in Immunology, 2021 - frontiersin.org
Nuclear receptors are important bridges between lipid signaling molecules and transcription
responses. Beside their role in several developmental and physiological processes, many of …
responses. Beside their role in several developmental and physiological processes, many of …
[HTML][HTML] Non-genomic AhR-signaling modulates the immune response in endotoxin-activated macrophages after activation by the environmental stressor BaP
H Großkopf, K Walter, I Karkossa… - Frontiers in …, 2021 - frontiersin.org
Emerging studies revealed that the Aryl hydrocarbon receptor (AhR), a receptor sensing
environmental contaminants, is executing an immunomodulatory function. However, it is an …
environmental contaminants, is executing an immunomodulatory function. However, it is an …