Early human embryonic development: Blastocyst formation to gastrulation
J Rossant, PPL Tam - Developmental cell, 2022 - cell.com
There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines
Summary The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last
revised in 2016. Since then, rapid progress has been made in research areas related to in …
revised in 2016. Since then, rapid progress has been made in research areas related to in …
Parental genome unification is highly error-prone in mammalian embryos
Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …
Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes
K Harasimov, J Uraji, EU Mönnich, Z Holubcová… - Nature Cell …, 2023 - nature.com
Accurate chromosome segregation during meiosis is crucial for reproduction. Human and
porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly …
porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly …
Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering
Gastrulation is a fundamental and critical process of animal development whereby the mass
of cells that results from the proliferation of the zygote transforms itself into a recognizable …
of cells that results from the proliferation of the zygote transforms itself into a recognizable …
[HTML][HTML] Single-cell multi-omics and lineage tracing to dissect cell fate decision-making
L Haghverdi, LS Ludwig - Stem Cell Reports, 2023 - cell.com
The concept of cell fate relates to the future identity of a cell, and its daughters, which is
obtained via cell differentiation and division. Understanding, predicting, and manipulating …
obtained via cell differentiation and division. Understanding, predicting, and manipulating …
NANOG initiates epiblast fate through the coordination of pluripotency genes expression
N Allègre, S Chauveau, C Dennis, Y Renaud… - Nature …, 2022 - nature.com
The epiblast is the source of all mammalian embryonic tissues and of pluripotent embryonic
stem cells. It differentiates alongside the primitive endoderm in a “salt and pepper” pattern …
stem cells. It differentiates alongside the primitive endoderm in a “salt and pepper” pattern …
The role of BMP4 signaling in trophoblast emergence from pluripotency
RM Roberts, T Ezashi, J Temple, JR Owen… - Cellular and Molecular …, 2022 - Springer
Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …
Criteria for the standardization of stem-cell-based embryo models
Pluripotent stem cells are being used to generate models of early embryogenesis that are
promising for discovery and translational research. To be useful, these models require …
promising for discovery and translational research. To be useful, these models require …