Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics

SL Kordus, AK Thomas, DB Lacy - Nature Reviews Microbiology, 2022 - nature.com
Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …

The role of toxins in Clostridium difficile infection

R Chandrasekaran, DB Lacy - FEMS microbiology reviews, 2017 - academic.oup.com
Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …

Clostridium difficile Toxin Biology

K Aktories, C Schwan, T Jank - Annual review of microbiology, 2017 - annualreviews.org
Clostridium difficile is the cause of antibiotics-associated diarrhea and pseudomembranous
colitis. The pathogen produces three protein toxins: C. difficile toxins A (TcdA) and B (TcdB) …

[HTML][HTML] Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects

S Di Bella, P Ascenzi, S Siarakas, N Petrosillo… - Toxins, 2016 - mdpi.com
Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly
and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly …

Clostridium difficile Toxins: Mechanism of Action and Role in Disease

DE Voth, JD Ballard - Clinical microbiology reviews, 2005 - Am Soc Microbiol
As the leading cause of hospital-acquired diarrhea, Clostridium difficile colonizes the large
bowel of patients undergoing antibiotic therapy and produces two toxins, which cause …

The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?

J Bien, V Palagani, P Bozko - Therapeutic advances in …, 2013 - journals.sagepub.com
Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian
gastrointestinal tract. They display a symbiotic relationship with the host contributing to its …

Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system

CI Dubreuil, MJ Winton, L McKerracher - The Journal of cell biology, 2003 - rupress.org
Growth inhibitory proteins in the central nervous system (CNS) block axon growth and
regeneration by signaling to Rho, an intracellular GTPase. It is not known how CNS trauma …

The induction of apoptosis by bacterial pathogens

Y Weinrauch, A Zychlinsky - Annual Reviews in Microbiology, 1999 - annualreviews.org
▪ Abstract Apoptosis is a highly regulated process of cell death that is required for the
development and homeostasis of multicellular organisms. In contrast to necrosis, apoptosis …

[HTML][HTML] Coral pathogens identified for white syndrome (WS) epizootics in the Indo-Pacific

M Sussman, BL Willis, S Victor, DG Bourne - PLoS one, 2008 - journals.plos.org
Background White Syndrome (WS), a general term for scleractinian coral diseases with
acute signs of advancing tissue lesions often resulting in total colony mortality, has been …

Strain-Dependent Induction of Enterocyte Apoptosis by Giardia lamblia Disrupts Epithelial Barrier Function in a Caspase-3-Dependent Manner

AC Chin, DA Teoh, KGE Scott, JB Meddings… - Infection and …, 2002 - Am Soc Microbiol
We recently demonstrated that Giardia lamblia rearranges cytoskeletal proteins and reduces
transepithelial electrical resistance. The effect of G. lamblia on enterocyte apoptosis is …