A review of cell-based computational modeling in cancer biology
Cancer biology involves complex, dynamic interactions between cancer cells and their
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …
Agent-based methods facilitate integrative science in cancer
In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …
[HTML][HTML] In silico trials: Verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products
Historically, the evidences of safety and efficacy that companies provide to regulatory
agencies as support to the request for marketing authorization of a new medical product …
agencies as support to the request for marketing authorization of a new medical product …
[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
Multiscale agent-based and hybrid modeling of the tumor immune microenvironment
Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …
playing increasingly important roles in understanding the fundamental mechanisms of …
Multi-scale spatial analysis of the tumor microenvironment reveals features of cabozantinib and nivolumab efficacy in hepatocellular carcinoma
Background Concomitant inhibition of vascular endothelial growth factor (VEGF) and
programmed cell death protein 1 (PD-1) or its ligand PD-L1 is a standard of care for patients …
programmed cell death protein 1 (PD-1) or its ligand PD-L1 is a standard of care for patients …
Mathematical models of tumor cell proliferation: A review of the literature
Introduction: A defining hallmark of cancer is aberrant cell proliferation. Efforts to understand
the generative properties of cancer cells span all biological scales: from genetic deviations …
the generative properties of cancer cells span all biological scales: from genetic deviations …
Virtual patients, digital twins and causal disease models: paving the ground for in silico clinical trials
P Moingeon, M Chenel, C Rousseau, E Voisin… - Drug discovery today, 2023 - Elsevier
Highlights•Predictive computational models are useful to complement clinical trials.•Disease
models that infer causality in pathophysiology have been produced.•Quantitative System …
models that infer causality in pathophysiology have been produced.•Quantitative System …
Multi-scale modeling of macrophage—T cell interactions within the tumor microenvironment
CG Cess, SD Finley - PLoS computational biology, 2020 - journals.plos.org
Within the tumor microenvironment, macrophages exist in an immunosuppressive state,
preventing T cells from eliminating the tumor. Due to this, research is focusing on …
preventing T cells from eliminating the tumor. Due to this, research is focusing on …
Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model
Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM)
are powerful and efficient approaches for the analysis of biological systems and for clinical …
are powerful and efficient approaches for the analysis of biological systems and for clinical …