This review explores the multifaceted role that iron has in cancer biology. Epidemiological
studies have demonstrated an association between excess iron and increased cancer …

Iron as an important element plays crucial roles in various physiological and pathological
processes. Iron metabolism behaves in systemic and cellular two levels that usually are in …

Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Demanded as an essential trace element that supports cell growth and basic functions, iron
can be harmful and cancerogenic though. By exchanging between its different oxidized …

New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …

Abstract The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-
dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis …

Cancer is the second most frequent cause of death worldwide, with 28.4 million new cases
expected for 2040. Despite de advances in the treatment, it remains a challenge because of …

Leukocytes, including macrophages and T cells, represent key players in the human
immune system, which plays a considerable role in the development and progression of …

Significance: Cancer cells accumulate high levels of iron and reactive oxygen species
(ROS) to promote their high metabolic activity and proliferation rate. However, high levels of …

Cancer cells undergo substantial metabolic alterations to sustain increased energy supply
and uncontrolled proliferation. As an essential trace element, iron is vital for many biological …